Python is a versatile language for game development. Pygame and Pyglet are popular libraries for 2D game development, providing functions for graphics rendering, sound playback, and user input handling. Panda3D offers a feature-rich framework for creating immersive 3D experiences. PyOpenGL provides high-performance graphics using the OpenGL API. Arcade is beginner-friendly, while Ren'Py specializes in interactive storytelling. Python's libraries make it suitable for games of various genres and complexities.